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Roles of m6A-modified circRNAs in immunity. m6A can mark “self” circRNAs and these endogenous circRNAs inhibite innate immune responses, whereas exogenous circRNAs can activate innate immunity by activating RIG-I in the presence of K63-polyubiquitin. In tumor immunity, circRNAs may inhibit tumor progression by inducing anti-tumor immunity.
