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. 2021 Jul 23;12:697157. doi: 10.3389/fimmu.2021.697157

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Copyright © 2021 Li, Li, Wu, Li, Yang, Wu, Xu, Luo, Gao, Fei and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative transmission electron micrograph (TEM) images of acinar-specific ultrastructure changes in the labial salivary gland of non-pSS and pSS. In non-pSS (Grade II), the structure of the acinar is normal, and the glandular epithelial cells in the acinar are myoepithelial cells. The cytoplasmic skeletal components and their unique myofilaments could be seen. With the aggravation of pSS, there is serous and mucous acini atrophy, glandular epithelial cell nucleus shrinkage, organelle swelling to varying degrees, and increase of interstitial collagen components. MD, Mucous Droplets; N, Nucleus; MC, myoepithelial cell; C, collagen; LD, lipid droplets. Bar: 5 μm, 1 μm, 500 nm.