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. 2021 Jul 23;9:697939. doi: 10.3389/fcell.2021.697939

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Copyright © 2021 Verel-Yilmaz, Fernández, Schäfer, Nevermann, Cook, Gercke, Helmprobst, Jaworek, Pogge von Strandmann, Pagenstecher, Bartsch, Bartsch and Slater.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cartoon of protocol for flow cytometry (FACS) (A). FACS analyses of serum EVs isolated from healthy individuals (B), patients with precursor lesions (C) or PDAC (D), attached to beads and detected with ADAM8 antibody. Results with secondary antibody alone appear in gray and those with both ADAM8 antibody and secondary antibody appear in red. Exemplary comparison of results for FACS analyses of serum exosomes from healthy controls (n = 4, E), precursor lesions (n = 5, F) or PDAC (n = 5, G) with ADAM8 (green) or Flotillin-1 (ochre) antibodies. Graphic representation of results from FACS analysis of EVs isolated from healthy individuals, patients with precursor lesions or PDAC from the total cohort, attached to beads and detected with ADAM8 antibody (H).