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. 2021 Jul 23;9:697939. doi: 10.3389/fcell.2021.697939

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Copyright © 2021 Verel-Yilmaz, Fernández, Schäfer, Nevermann, Cook, Gercke, Helmprobst, Jaworek, Pogge von Strandmann, Pagenstecher, Bartsch, Bartsch and Slater.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity assay of ADAM8 in serum EVs isolated from healthy control (A) or PDAC patient (B). Results of the test set using 7 oncomiRs with black boxes, controls, and red boxes, PDAC patients (C). Boxplots of the (miR-451–Cel-54) (D) and (miR-720—Cel-54) (F) ΔΔCt values (patient minus healthy control) in the four groups (con, healthy control; CP, chronic pancreatitis; precursor lesions; and PDACs, pancreatic ductal adenocarcinoma). ROC curves for the comparison of exo-miR-451 (E) and exo-miR-720 (G) expression levels between patients with PDAC and healthy controls. ΔCt values for miRNAs isolated from EVs secreted by wild type Panc89 (orange) and ADAM8 knock-out cells (gray) (H).