TABLE 3.
Univariate and multivariate analysis of clinicopathologic factors in HNSCC patients with respect to OS.
| Characteristics | Cases, n (%) | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| Survival time (month) | p value | HR (95% CI) | p value | ||
| Gender | |||||
| Male | 64 (80.0) | 56.23 ± 5.04 | 0.419 | ||
| Female | 16 (20.0) | 61.94 ± 8.54 | |||
| Age (years) | |||||
| ＜60 | 49 (61.3) | 54.45 ± 5.33 | 0.594 | ||
| ≥60 | 31 (38.8) | 61.46 ± 7.33 | |||
| Localization | |||||
| Oropharynx | 17 (21.3) | 46.30 ± 7.24 | 0.998 | ||
| Non-oropharynx | 63 (78.8) | 58.50 ± 5.00 | |||
| Histology | |||||
| Well differentiated | 18 (22.5) | 72.75 ± 8.51 | 0.058 | 0.278 | |
| Moderately differentiated | 47 (58.8) | 54.83 ± 5.51 | |||
| Poorly differentiated | 15 (18.8) | 37.20 ± 6.57 | |||
| TNM stage | |||||
| Ⅰ/Ⅱ | 33 (41.3) | 74.07 ± 6.07 | 0.001 | 0.183 | |
| Ⅲ/Ⅳ | 47 (58.8) | 45.54 ± 5.38 | |||
| Tumor size | |||||
| ≤4 cm | 48 (60.0) | 64.28 ± 5.41 | 0.019 | 0.687 | |
| ＞4 cm | 32 (40.0) | 46.03 ± 6.59 | |||
| Lymph node metastasis | |||||
| Negative (N0) | 49 (61.3) | 71.03 ± 5.64 | 0.000 | 2.111 (1.111–4.013) | 0.023 |
| Positive (N1-3) | 31 (38.8) | 37.65 ± 5.35 | |||
| Tobacco smoking | |||||
| Non-smoker | 28 (35.0) | 57.30 ± 7.02 | 0.676 | ||
| Smoker | 52 (65.0) | 56.87 ± 5.53 | |||
| Alcohol consumption | |||||
| Non-drinker | 37 (46.3) | 54.55 ± 6.10 | 0.827 | ||
| Drinker | 43 (53.8) | 58.81 ± 6.04 | |||
| p16 status | |||||
| Negative | 26 (32.5) | 65.90 ± 7.52 | 0.120 | ||
| Positive | 54 (67.5) | 53.33 ± 5.30 | |||
| TIM-3+ TILs count | |||||
| Low | 41 (51.3) | 76.98 ± 5.76 | 0.000 | 2.066 (1.027–4.159) | 0.042 |
| High | 39 (48.8) | 37.85 ± 5.08 | |||
| CEACAM1+ TILs count | |||||
| Low | 40 (50.0) | 69.39 ± 6.10 | 0.015 | 0.152 | |
| High | 40 (50.0) | 45.81 ± 5.76 | |||
| CEACAM1 | |||||
| Low | 41 (51.3) | 83.67 ± 4.80 | 0.000 | 5.885 (2.832–12.230) | 0.000 |
| High | 39 (48.8) | 30.80 ± 4.59 | |||