TABLE 4.
Univariate and multivariate analysis of clinicopathologic factors in HNSCC patients with respect to DFS.
| Characteristics | Cases, n (%) | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| Survival time (month) | p value | HR (95% CI) | p value | ||
| Gender | |||||
| Male | 64 (80.0) | 45.10 ± 4.94 | 0.284 | ||
| Female | 16 (20.0) | 57.19 ± 9.34 | |||
| Age (years) | |||||
| ＜60 | 49 (61.3) | 47.35 ± 5.67 | 0.891 | ||
| ≥60 | 31 (38.8) | 42.65 ± 5.81 | |||
| Localization | |||||
| Oropharynx | 17 (21.3) | 42.37 ± 8.12 | 0.805 | ||
| Non-oropharynx | 63 (78.8) | 47.20 ± 4.92 | |||
| Histology | |||||
| Well differentiated | 18 (22.5) | 70.94 ± 9.19 | 0.045 | 0.234 | |
| Moderately differentiated | 47 (58.8) | 41.35 ± 5.14 | |||
| Poorly differentiated | 15 (18.8) | 32.20 ± 7.43 | |||
| TNM stage | |||||
| Ⅰ/Ⅱ | 33 (41.3) | 63.90 ± 6.40 | 0.001 | 0.206 | |
| Ⅲ/Ⅳ | 47 (58.8) | 35.92 ± 5.29 | |||
| Tumor size | |||||
| ≤4 cm | 48 (60.0) | 55.91 ± 5.73 | 0.016 | 0.572 | |
| ＞4 cm | 32 (40.0) | 34.91 ± 6.20 | |||
| Lymph node metastasis | |||||
| Negative (N0) | 49 (61.3) | 56.92 ± 5.56 | 0.002 | 2.253 (1.237–4.102) | 0.008 |
| Positive (N1-3) | 31 (38.8) | 31.48 ± 5.99 | |||
| Tobacco smoking | |||||
| Non-smoker | 28 (35.0) | 51.14 ± 7.55 | 0.640 | ||
| Smoker | 52 (65.0) | 44.36 ± 5.18 | |||
| Alcohol consumption | |||||
| Non-drinker | 37 (46.3) | 48.32 ± 6.56 | 0.964 | ||
| Drinker | 43 (53.8) | 45.48 ± 5.70 | |||
| p16 status | |||||
| Negative | 26 (32.5) | 57.75 ± 7.99 | 0.114 | ||
| Positive | 54 (67.5) | 42.48 ± 5.07 | |||
| TIM-3+ TILs count | |||||
| Low | 41 (51.3) | 63.77 ± 5.85 | 0.000 | 0.094 | |
| High | 39 (48.8) | 29.76 ± 5.10 | |||
| CEACAM1+ TILs count | |||||
| Low | 40 (50.0) | 59.61 ± 6.17 | 0.011 | 0.753 | |
| High | 40 (50.0) | 35.09 ± 5.57 | |||
| CEACAM1 | |||||
| Low | 41 (51.3) | 73.21 ± 5.15 | 0.000 | 7.143 (3.623–14.085) | 0.000 |
| High | 39 (48.8) | 20.43 ± 3.89 | |||