Table 2.
Synergism of miltefosine with fluconazole, caspofungin and myriocin against Scedosporium aurantiacum.
| MIC (μg/ml) alone | |
|---|---|
| MLT | 4 |
| FLC | 25 |
| CAS | 25 |
| MYR | 16 |
| MIC (μg/ml) in combination | |
| MLT/FLC | 2/12.5 |
| MLT/CAS | 1/1.57 |
| MLT/MYR | 2/1 |
| FIC index | |
| MLT–FLC | 1.0 (no effect) |
| MLT–CAS | 0.31 (synergic) |
| MLT–MYR | 0.56 (no effect) |
MIC, minimum inhibitory concentration; MTL, miltefosine; FLC, fluconazole; CAS, caspofungin; MYR, myriocin.
Experiments were performed in triplicate, in three independent experimental sets, to calculate FICI).