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. 2021 Jan 23;11(7):1835–1852. doi: 10.1016/j.apsb.2021.01.015

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© 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — GRK2 and EP4 expression in synovial tissues of CIA rats. (A) Representative micrographs of HE-stained histological sections of the joints are shown. The histology section of the joints shows the synoviocytes (S), the pannus formation (P), the inflammatory cells (I), the bone (B), and the cartilage (C) (n = 6). Data are expressed as mean ± SD. ^∗P < 0.05, ^∗^∗P < 0.01 vs. CIA group. Scale bars = 100 μm. (B) The effect of CP-25 on the expression of GRK2 and EP4 in the synovial cells of CIA rats was detected by immunohistochemistry assay (n = 6). Arrows indicated the FLS of CIA rats. Scale bars = 50 μm. (C) The effect of CP-25 on the distribution of GRK2 and EP4 in the synovial cells of CIA rats was detected by laser scanning confocal microscope (n = 6). Arrows indicated the FLS of CIA rats. Scale bars = 25 μm. Data are expressed as mean ± SD. ^#P < 0.05 vs. normal group; ∗P < 0.05, ^∗∗P < 0.01 vs. CIA group.