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. 2021 Jan 23;11(7):1835–1852. doi: 10.1016/j.apsb.2021.01.015

Figure 4.

Fig. 4

GRK2 knockdown strongly inhibits the proliferation of FLS, possibly via PGE2–EP4 signaling pathway. (A) Grk2 siRNA was transfected into FLS, the inhibition rate of GRK2 was detected by Western blot (n = 4). (B) FLS proliferation was detected by high content cell imaging system images (n = 6). (C) The co-expression of GRK2 and EP4 was detected by laser confocal microscopy (n = 6). Scale bars = 50 μm. Data are expressed as mean ± SD. #P < 0.05, ##P < 0.01 vs. control group; $P < 0.05 vs. negative control group with PGE2.