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. 2021 Jul 23;12:708904. doi: 10.3389/fmicb.2021.708904

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Copyright © 2021 Gil, Pastar, Houghten, Padhee, Higa, Solis, Valdez, Head, Michaels, Lenhart, Simms, Williams, Cudic and Davis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CLP 2605-4 treatment inhibited wound closure. (A) Graph showing percentage of epithelialization for all treatment groups at days 5, 7, and 10 post-treatment. The amount of re-epithelialized tissue was calculated as a percentage of the wounded area that was covered by newly formed epidermis. Treatment with CLP 2605-4 resulted in inhibition of epithelialization compared to other treatment groups (*p ≤ 0.05). (B) Representative wounds at day 10 stained with H&E are shown. Red arrows indicate extent of wound edges in CLP 2605-4 treated wounds indicating wound gap. Enlargements show epidermis fully covering wounds treated with CLP 2612-8.1, vehicle and untreated control wounds. Scale bar = 1000 μm.