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. 2021 Jul 23;12:708904. doi: 10.3389/fmicb.2021.708904

FIGURE 6.

FIGURE 6

CLP treatment affected granulation tissue formation. Comparative scores of granulating wound bed assessed on days 5, 7, and 10 from tissue section stained with H&E (1 = ≤ 5%, 2 = 6–25%, 3 = 26–50%, 4 = 51–75%, 5 = 76–100%). Statistically significant difference in granulation tissue formation was observed during progression of wound healing. Reduced levels of granulation tissue were observed on day 5 in CLP 2605-4 and CLP 2612-8.1 treated wounds compared to vehicle and untreated control (*p < 0.05). Statistically significant reduction in granulation tissue formation was also found in CLP 2605-4 treated wounds compared to vehicle and untreated control at days 7 and 10 (*p < 0.05). n = 8 per each treatment group, per time point.