. 2021 Jul 23;12:659012. doi: 10.3389/fgene.2021.659012

TABLE 3.

Summary of genes with variants and high impact variants within QTL CIs.

QTL	Genes	SNP or InDel	SV	High Impact	cis eQTL	Priority Genes
Chr 11: Mobility and Hypothermia (M)	212	130	34	60	33	*Rps6kb1/p70s6k^C, Aatf^C, Acaca^HCP. Akap1^YCN, Ankfn1^Y, Bcas3^Y, Car4^S, Ccl1, Ccl11, Ccl3, Ccl5, Cltc^C, Cuedc1^HC, Dgke^HYC, Dhrs11^Y, Dhx40^H, Dynll2^Y, Gdpd1/Gde4, Ggnbp2^C, Heatr6^HYCN, Mks1^Y, Mrm1^C, Mrps23^H, Msi2^HC, Myo19^Y, Ppm1d^HN, Scpep1^HY, Slfn8^C, Trim25^CN, Usp32^HN, Wfdc18*^C
Chr 19: Hypothermia (M)	105	53	6	3	5	*Pten^N, 2700046G09Rik^HYCN, Atad1^HN, Papss2^HCN*,
Chr 13: Hypothermia (F)	107	46	8	8	12	*Pde4d^CS, Ercc8^C, Map3k1^C, Plk2^N, Plpp1^P, Rab3c^HC, Zswim6*^H
Chr 1: Antinociception	91	60	11	29	23	*Ndufs2*^HYCNP, *Adamts4*^HCN, *Alyref2*^CN, *Arhgap30^H, Cd84*^CN, *Fcer1g*^HYC, *Fcgr3*^YCS, *Klhdc9^Y, Nit1H*^YCNP, *Pfdn2*^HYNP, *Ppox*^HCNPS, *Sdhc*^HCNPS, *Ufc1*^HCNP, *Usp21*^C
Chr 4: Antinociception	107	68	15	14	16	*Scp2*^CP, Acot11^HYN, Cc2d1b^Y, Kti12^N, Mroh7^YC, Ndc1^HC, Podn^C, *Rab3b, Tceanc2^YCS, Txndc12^C, Zcchc11^HN, Zfyve9^HCN, Zyg11b^HNP*

Number of genes or non-coding RNA (ncRNA) within each interval (Genes column), number of genes or ncRNA near or overlapping a SNP or InDel (SNP or InDel column), number of genes or ncRNA overlapping a SV (SV column), and number of genes or ncRNA containing a high impact SNP or InDel (High Impact column) are shown for each THC initial response QTL. Number of genes within each QTL CI whose expression is regulated by a cis eQTL are shown in the cis eQTL column. High priority candidate QTL genes (QTGs) associated through literature searches with endocannabinoid/cannabinoid signaling (underline) whose expression, is regulated by a cis eQTL in at least one brain region (Y = hypothalamus, C = neocortex, S = striatum, N = nucleus accumbens, P = prefrontal cortex) and/or overlap a SV or high impact SNP or InDel (bold) are shown in the Priority Genes column.