Table 3.

Effects of 15q11.2 BP1-BP2 Copy Number Variation on Cognitive Performance in UK Biobank Participants for Whom DTI Data Were Available

Effects	15q11.2 BP1-BP2 CNVs			Deletion vs NoCNV			Duplication vs NoCNV			Dosage
	Deletion, n	NoCNV, n	Duplication, n	Cohen’s d (SE)	p Value	pFDR	Cohen’s d (SE)	p Value	pFDR	F Statistic	p Value
Pairs Matching	102	28,599	112	−0.04 (0.10)	.63	.80	0.01 (0.10)	.88	.9	F2,28805 = 0.17	.8
Reaction Time	102	28,898	113	−0.32 (0.10)	.001	.01a	0.17 (0.10)	.07	.1	F2,29105 = 7.14	.0008
Fluid Intelligence	89	26,690	108	−0.32 (0.10)	.003	.01a	−0.04 (0.10)	.71	.8	F2,26879 = 4.33	.01
Digit Span	71	19,799	81	−0.29 (0.12)	.02	.05	−0.1 (0.12)	.38	.5	F2,19943 = 3.27	.04
Symbol Substitution	62	15,127	55	−0.36 (0.13)	.005	.02a	0.13 (0.13)	.33	.5	F2,15236 = 4.79	.008
Trail Making A	52	13,538	48	−0.29 (0.14)	.04	.09	−0.04 (0.14)	.80	.8	F2,13630 = 2.52	.08
Trail Making B	52	13,538	48	−0.40 (0.14)	.004	.02a	0.19 (0.14)	.20	.3	F2,13630 = 5.67	.003

Group differences were assessed using ANOVA followed by post hoc pairwise comparisons. Both uncorrected and FDR-corrected p values are shown.

ANOVA, analysis of variance; BP, breakpoint; CNV, copy number variant; FDR, false discovery rate; NoCNV, no pathogenic CNVs.

^ap < .05 after FDR correction.