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. 2021 Jul 23;12:690534. doi: 10.3389/fimmu.2021.690534

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Copyright © 2021 Ciocca, Zaffina, Fernandez Salinas, Bocci, Palomba, Conti, Terreri, Frisullo, Giorda, Scarsella, Brugaletta, Vinci, Magnavita, Carsetti and Piano Mortari

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Identification of naive, CD27^dull, and CD27^bright MBCs at the indicated ages. (B, C) Percentage and absolute numbers of (B) CD27^dull and (C) CD27^bright MBCs. (D) Ratio of CD27^dull and CD27^bright MBCs at the indicated ages (children n = 37; young n = 18; 65 ≥years <70 n = 21; over 70 years n = 9). Midlines indicate the median values. Statistical significances were determined using unpaired, two-tailed Mann-Whitney U-tests. *p ≤ 0.05; **p < 0.01; ***p < 0.001.