FIGURE 6.

Cacna1c expression and Ca²⁺ level. Protein expressions of Cacna1c were downregulated in the aortic endothelial cells from hypertensive mice, which were rescued by MK-626 (A–B). The reduced Ca²⁺ level was also restored after MK-626 administration in the endothelial cells of hypertensive mice (C–D). ^** p < 0.01, ^**** p < 0.0001 vs Vehicle; ^# p < 0.05, ^#### p < 0.0001 vs Ang Ⅱ. Data are expressed as mean ± SEM (n = 4–6 for Western blot; n = 80 individual cells for the measurement of Ca²⁺ level, scale bar = 100 μm). A + M, Ang Ⅱ + MK-626.