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. 2021 Jul 23;8:724225. doi: 10.3389/fmolb.2021.724225

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Copyright © 2021 Zhang, Tan, Zong, Li, Zhang, Liu, Wang, Han and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of lncRNA ENSMUST00000155383 silence. Small interfering RNA (siRNA) of lncRNA ENSMUST00000155383 reduced Cacna1c mRNA level (A) and protein expression (B) in the aortic endothelial cells from hypertensive mice. Silencing lncRNA ENSMUST00000155383 resulted in the reduction of Ca²⁺ level (C) and eNOS phosphorylation (D) in the MAECs in hypertension. ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001 vs NC siRNA. Data are expressed as mean ± SEM. (n = 4–6 for Western blot; n = 80 individual cells for the measurement of Ca²⁺ level, scale bar = 75 μm). 155383, lncRNA ENSMUST00000155383; A + M, Ang Ⅱ + MK-626.