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. 2020 Nov 17;11(7):1947–1964. doi: 10.1016/j.apsb.2020.11.004

Table 2.

Structure and ANO1 inhibitory IC50 of 4-arylthiophene-3-carboxylic acid derivatives.

Image 36
Compd. R1 R2 IC50 (μmol/L)a
1 – – 2.1
28 Image 37 Image 38 6.38
33 Image 39 Image 40 9.62
34 Image 41 Image 42 1.34
35 Image 43 Image 44 >100
36 Image 45 Image 46 3.67
37 Image 47 Image 48 2.30
38 Image 49 Image 50 >100
39 Image 51 Image 52 1.29
40 Image 53 Image 54 25.51
41 Image 55 Image 56 2.28
42 Image 57 Image 58 0.79
43 Image 59 Image 60 2.45
44 Image 61 Image 62 1.24
45 Image 63 Image 64 1.74
46 Image 65 Image 66 14.50
a

IC50 value was determined by YFP fluorescence quenching assay. Data are represented by mean ± SEM, n = 3.