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. 2021 Jul 23;12:669103. doi: 10.3389/fimmu.2021.669103

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Copyright © 2021 Fu, Lei, Ma, Qian, Li, Zhao and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CARs mediate protection against SARS-CoV-2 infection. (A) The schematic shows the transwell coculture model. Figure created with BioRender. (B) Different cell cocultures were inoculated with the SARS-CoV-2 pseudotyped virus in the culture plate. At 16 h post inoculation, pseudotyped virus entry was analyzed by determining the luciferase activity in cell lysates of Vero cells. Signals obtained for particles bearing no envelope protein were used for normalization. Data are presented as the mean ± s.d. (a–c) of four independent biological replicates. P values were derived by one-way ANOVA followed by Tukey’s posttest. ****p<0.0001. NS, Not Significant. The circles represent individual data (B).