Figure 2.

Aβ plaques appear in various brain regions of 5xFAD mice already at 4 months. (A,B) Images of brain slices stained with thioflavine S (green) that labels Aβ plaques from a (A) WT and (B) 5xFAD mice. Brain regions including olfactory bulb (OB), hippocampus (HP), and visual cortex (VC) were enlarged in Panels (C) and (D), respectively, for WT and 5xFAD. (E) Number of Aβ plaques in different brain regions of WT and 5xFAD at 4 and 6 months. At 4 months, 5xFAD mice have more Aβ plaques in the brain than WT. Data shown as mean ± SEM. ***p < 0.001, two-way ANOVA test.