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. 2021 Jul 23;15:681831. doi: 10.3389/fnins.2021.681831

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Copyright © 2021 Zhang, Zhong, Han, Xiong, Xu, Zhang, Cheng, Chiu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Density of retinal ganglion cells is normal in 5xFAD but a few Aβ plaques emerge in retina at 6 months. (A) Example of Brn3a staining of RGCs (green) and Aβ plaque deposition (red, examples indicated by white arrows) from a whole mount retina of a WT and 5xFAD mice at 6 months; the white square from similar eccentricity is shown in Panel (B) at higher magnification. (C) Images of retinal slices stained with DAPI and Aβ plaque deposition (red, points by white arrow). (D) Scattered plot of the Brn3a-positive cell density in whole mount retina at central (cent), middle (mid), and peripheral (peri) regions (corresponding to 300, 1,000, and 1,700 μm away from the center of the optic disk, respectively). The RGCs density in 5xFAD is similar to that of WT at both 4 and 6 months. (E) Scattered plot of Aβ plaque number in retinal slices (accumulated from three slices for each animal). **p < 0.01; two-way ANOVA.