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. 2021 Jul 23;15:681831. doi: 10.3389/fnins.2021.681831

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Copyright © 2021 Zhang, Zhong, Han, Xiong, Xu, Zhang, Cheng, Chiu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reactive gliosis happens in 5xFAD at 6 months. (A) Images of Iba1 staining (green) on whole mount retinas of WT and 5xFAD mice at 4 and 6 months. (B) Number of Iba1+ cells on retina (an image size of 320×320 μm). (C) Images of GFAP staining (green) on retinal sections of WT and 5xFAD mice at both ages. Note the difference in scale. (D) The GFAP intensity in the inner retina, normalized to the WT control. ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer. Data shown as mean ± SEM. **p < 0.01; ***p < 0.001, two-way ANOVA.