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. 2021 Jul 23;9:659680. doi: 10.3389/fcell.2021.659680

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Copyright © 2021 Zhang, Chen, Li, Li, Zhao, Xiao, Liu and Zuo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transfecting c-Jun increases the CCND1 signal and restores cell proliferation in NAP1L1-suppressing HCC cells. (A) Quantitative RT-qPCR data to measure c-Jun expression after restoring c-Jun in shNAP1L1 HCC cells. (B) NAP1L1, HDGF, c-Jun, and CCND1 protein sequences in HDGF restored shNAP1L1 HCCLM3 (scale bar: 200 μm). (C) MTT assays showed that transfecting c-Jun restores cell proliferation. (D) EdU assay showed that transfecting c-Jun restores cell proliferation (scale bar: 200 μm). *p < 0.05 vs. control; **p < 0.01; ***p < 0.001.