Table 3.
Twelve-hour values in exploratory outcomes. shown are mean ± SD in exploratory outcomes at baseline and twelve hours from intervention. P-values from Wilcoxon signed rank sum test. *One participant was excluded from analysis of baroreflex sensitivity because there were too many ectopic beats in the continuous ECG.
| Baseline | Dapagliflozin | Placebo | p | |
|---|---|---|---|---|
| Autonomic Nerve Function and Blood Oxygenation | ||||
| Baroreflex Sensitivity (ms/mmHg)* | 8 ± 7 | 7 ± 5 | 6 ± 4 | 0·903 |
| Blood Oxygen Saturation (%) | 96 ± 2 | 95± 3 | 96 ± 1 | 0·252 |
| Peripheral Blood Mononuclear Cells Mitochondrial Oxygen Consumption Rate ((pmol/min)/cell number)x10−5) | ||||
| Basal Respiration | 8 ± 3 | 8 ± 3 | 8 ± 3 | 0·561 |
| ATP Production | 6 ± 2 | 7 ± 2 | 7 ± 2 | 0·679 |
| Maximal Respiration | 23 ± 10 | 24 ± 12 | 24 ± 8 | 0·421 |
| Spare Respiratory Capacity | 15 ± 8 | 16 ± 9 | 16 ± 6 | 0·330 |
| Non-mitochondrial Respiration | 1·8 ± 0·7 | 1·7 ± 0·9 | 2·0 ± 0·9 | 0·489 |
| Proton Leak | 1·7 ± 0·6 | 1·6 ± 0·6 | 1·6 ± 0·6 | 0·489 |