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. 2021 Feb 19;16(10):2093–2098. doi: 10.4103/1673-5374.308667

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Copyright: © 2021 Neural Regeneration Research

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Fluoxetine specifically increased the voiding efficiency in animals with moderate T10 spinal contusion injury.

(A, B) Expressed residual urine after VSOP from mice with severe (A) or moderate (B) T10 spinal contusion injuries following treatment with normal saline (NS), fluoxetine, duloxetine, buspirone, sumatriptan, or rizatriptan. (C–E) Comparisons of micturition volumes (C), bladder capacities (D), and voiding efficiencies (E) among animals with moderate T10 spinal contusion injuries treated with NS and fluoxetine. Data are expressed as the mean ± SEM (5A: n = 5, 4, 3, 3, 3, and 3; 5B: n = 5, 5, 4, 3, 3, and 3, in NS, saline, fluoxetine, duloxetine, buspirone, sumatriptan, and rizatriptan treatment groups, respectively). †P < 0.05, vs. NS group (one-way analysis of variance followed by Bonferroni’s post hoc test), ††P < 0.01, vs. normal saline group (Student’s t-test). cap: Bladder capacity; kdyn: kilodyne; mv: micturition volume; NS: normal saline; VSOP: voided stain on paper. 1 dyn = 10^–5 N.