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. 2021 Feb 19;16(10):2109–2120. doi: 10.4103/1673-5374.303537

Figure 10.

Figure 10

The JNK inhibitor SP600125 preserved the retinal morphology of rd10 mice (rd).

(A) Representative images of DAPI-stained retinal slices from rd10 mice treated with PBS, luteolin (lut), DMSO, or the JNK inhibitor SP600125 at P26. Scale bars: 20 μm. (B) ONL thickness in rd10 retinal slices at approximately 1 mm from the center of the optic disk. Treatment with luteolin or the JNK inhibitor increased ONL thickness compared with solvent controls. Data are expressed as mean ± SEM. *P < 0.05, ***P < 0.001 (Student’s t-test). Numbers within bars indicate quantities of mice tested. DAPI: 4′,6-Diamidino-2-phenylindole; DMSO: dimethyl sulfoxide; JNK: c-Jun N-terminal kinase; GCL: ganglion cell layer; INL: inner nuclear layer; ONL: outer nuclear layer; P: postnatal day; PBS: phosphate-buffered saline.