Figure 4.

Luteolin increases the survival of photoreceptors in rd10 mice.

(A) Images of DAPI staining of retinal sections. The ONL of retinas of PBS-treated rd10 mice (rd/PBS) was much thinner than that of WT controls, and was partly reversed by luteolin (rd/lut). Scale bars: 40 μm. (B) Quantification of ONL thickness at P26 in each group from center to peripheral regions. Data are expressed as mean ± SEM. *P < 0.05, ***P < 0.001 (one-way analysis of variance followed by Tukey’s post hoc test). Numbers within bars indicate quantities of mice tested. DAPI: 4′,6-diamidino-2-phenylindole; GCL: ganglion cell layer; INL: inner nuclear layer; ONL: outer nuclear layer; P: postnatal day; PBS: phosphate-buffered saline; WT: wild-type.