Figure 1.

Establishment of SCI mouse models and expression profiles of circRNA.

Light microscopy of HE-stained spinal cord samples at 5 days post-surgery. (A) Sham group (scale bars: 100 μm, left; 50 μm, right). (B) SCI group (scale bars: 100 μm, left; 50 μm, right). (C) Hierarchical clustering analysis of circRNAs differentially expressed between sham and SCI groups. Red pixels correspond to increased gene abundances in the indicated sample, whereas blue pixels indicate decreased gene abundances; fold-change > 2.0 and P < 0.05. (D) Volcano plot showing significantly differentially expressed circRNAs; red pixels represent differentially expressed genes, while gray pixels indicate genes with no difference; fold-change > 2.0 and P < 0.05. HE: Hematoxylin and eosin; SCI: spinal cord injury.