Table 5.
Literature review for studies evaluating efficacy of prone positioning in mechanically ventilated patients with COVID-19 ARDS
| Study author | Number of patients | Study region | Timing of response evaluation | Change in PaO2/FiO2 ratio (mmHg) | Change in compliance (mL/cmH2O) |
|---|---|---|---|---|---|
| Present study by Jimyung Park | 23 | South Korea | End of first proning session |
Median 107 (IQR 92–132) → median 196 (IQR 161–248) |
Median 27.2 (IQR 21.9–32.7) → median 31.5 (IQR 25.2–37.0) |
| Osama Abou-Arab [41] | 25 | France | End of first proning session |
Median 91 (95% CI 78–137) → median 124 (95% CI 97–149) |
Median 32 (95% CI 21–38) → median 32 (95% CI 23–40) |
| Alfredo J Astua [42] | 29 | U.S.A | End of first proning session |
Mean 107.5 ± 5.6 → mean 142.0 ± 10.8 |
N.A |
| Max Berrill [43] | 34 | U.K | End of every proning session |
Mean 99.8 ± 100 → mean 151.9 ± 58.9 |
N.A |
| Jennifer Clarke [44] | 20 | Ireland | During first proning session |
Median 123 (IQR 100–154) → median 286 (IQR 195–348) |
Median 33.7 (IQR 30.1–43.0) → median 32.5 (IQR 26.7–37.5) |
| Ivor S Douglas [45] | 61 | U.S.A | 2 h after starting proning |
Median 99 (IQR 73–128) → median 136 (IQR 105–164) |
N.A |
| Helena Gleissman [46] | 44 | Sweden | End of first proning session |
Median 104 (IQR 86–122) → median 161 (IQR 127–207) |
N.A |
| Rohit Khullar [47] | 23 | U.S.A | End of last proning session |
Mean 84.8 (SD N.A.) → mean 202.0 (SD N.A.) |
N.A |
| Thomas Langer [48] | 78 | Italy | End of first proning session |
Median 98 (IQR 72–121) → median 158 (IQR 112–220) |
Median 43 (IQR 31–50) → median 42 (IQR 35–48) |
| Mirja Mittermaier [49] | 9 | Germany | 12 h after starting proning |
Mean 118.4 ± 41.9 → mean 181.8 ± 63.2 |
N.A |
| François Perier [50] | 9 | France | 3 h after starting proning | N.A |
Median 44 (IQR 38–55) → median 39 (IQR 32–53) |
| Ling Sang [51] | 20 | China | End of first proning session |
Mean 68.0 ± 10.3 → mean 82.4 ± 15.5 |
Mean 17.5 ± 3.5 → mean 20.6 ± 4.4 |
| Gaetano Scaramuzzo [52] | 191 | Italy | 3 h after resupination | Median 49% improvement (IQR 19–100%) | N.A |
| Mehdi C Shelhamer [53] | 62 | U.S.A | During first proning session | Improvement by 36.4 mmHg (49% improvement) | N.A |
| Richard Vollenberg [54] | 13 | Germany | 6 h after starting proning | Median 58% improvement (IQR 31–95%) |
Median 38 (IQR 26–58) → median 39 (IQR 27–59) |
| Tyler T Weiss [29] | 36 | U.S.A | 2 h after starting proning |
Median 131 (IQR 87–144) → median 208 (IQR 146–268) |
Median 29.2 (IQR 23.3–35.5) → median 29.2 (IQR 24.0–36.2) |
| David R Ziehr [55] | 122 | U.S.A | End of first proning session |
Median 149 (IQR 123–170) → median 235 (IQR 186–285) |
Median 31 (IQR 27–39) → median 33 (IQR 28–38) |
CI confidence interval, FiO2 fraction of inspired oxygen, IQR interquartile range, N.A. not available, PaO2 partial pressure of oxygen, SD standard deviation