TABLE 4.

Studies regarding mesenchymal stromal cell-conditioned medium for treating wounds in human.

	MSC source	Method of tissue extraction	Indication	Study type	Age (years)	Sex (male:female)	Groups of treatments and via of administration	Follow-up (days)	Assessment	Main outcome
Prakoeswa et al., 2018	Human amniotic fluid	Amniocentesis	Chronic plantar ulcer in leprosy	Randomized controlled trial	52.18 ± 1.33	5:6	Topical application every 3 days - MSC-CM - MSC-CM+vitamin C - MSC-CM+vitamin E (n = 22/group)	56	Macroscopic appearance (photography), spectrophotometric	All groups reduced wound size and depth. Healing percentage increased in all groups. Size reduction was 1.7 ± 1.05 vs. 2.01 ± 1.19 vs. 2.84 ± 1.67 cm2, and depth was decreased 0.35 ± 0.14 vs. 0.25 ± 0.11 vs. 0.27 ± 0.15 cm in MSC-CM, MSC-CM+vitamin C, and MSC-CM+vitamin E group, respectively. No adverse events were reported

CM, conditioned medium; MSC, mesenchymal stromal cells.