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. 2021 Aug 2;5(8):ytab254. doi: 10.1093/ehjcr/ytab254
Event
10 days prior to admission Onset of fever, confusion, and fatigue
7 days prior to admission Transient loss of consciousness
Day 0 Patient presents to the emergency room with fever and fatigue. He is alert and haemodynamically stable. Twelve-lead electrocardiogram (ECG) and non-contrast head computed tomography (CT) are unremarkable
Day 1

Admission to internal ward

Initial fever workup does not identify the source of patient's symptoms

Day 2

Patient is placed on 24 h Holter ECG

Gradual cognitive impairment is noticed

Head CT angiography demonstrated changes at the left hemispheric blood vessels and lumbar puncture confirms herpes simplex encephalitis

Patient is started on parenteral Acyclovir

Day 3

Syncopal episode noticed by staff

Holter documents five episodes of sinus arrest; prominent ones being 11 and 32 s

Patient is transferred to intensive cardiac care unit

Day 5 Cognition is fully restored, fever subsides
Day 7 Patient is transferred back to internal ward, completes 14 days of parenteral Acyclovir treatment
Day 9 Subsequent Holter ECG revealed normal heart rate without any evidence of bradycardia
Day 16 Upon discharge an implanted loop recorder was considered but rejected by the patient
5 months later A follow-up Holter ECG documented normal heart rate and no evidence of bradycardia
12 months follow-up Patient is doing well and had no further episodes of syncope or documented bradycardia