Table 3.
Mean values of virological, hematological, and biochemical parameters in the two groups of patients with CHC, with or without TD
|
Parameter |
Mean values in patients with CHC with TD |
Mean values in patients with CHC without TD |
Statistical test p-value |
|
HCV-RNA quantitative testing [copies/mL] |
1 123 673±225 953.4 |
1 875 432±345 988.3 |
<0.001* |
|
Hb [g/dL] |
12.14±0.8 |
13.8±0.9 |
0.456 |
|
PLT count [No./mm3] |
158 216.2±24 143.4 |
271.148±29.512 |
0.054 |
|
WBC count [No./mm3] |
6278±1524 |
8454±1624 |
0.061 |
|
ESR [mm/1 h] |
15.7±6.19 |
13.7±4.16 |
0.09 |
|
CRP [mg/dL] |
16.27±7.74 |
8.1±4.28 |
0.16 |
|
IL-6 [ng/L] |
37.08±20.34 |
30.34±19.58 |
0.19 |
|
TNF-α [ng/L] |
54.62±42.93 |
29.88±20.16 |
0.009* |
|
TB [mg/dL] |
1.2±0.5 |
0.7±0.3 |
0.468 |
|
ALP [U/L] |
158±24 |
128±19 |
0.342 |
|
GGT [U/L] |
109±18 |
52±14 |
0.078 |
|
ALT [U/L] |
64±29.6 |
58±28.2 |
0.354 |
|
AST [U/L] |
57.2±26.4 |
49.5±25.4 |
0.378 |
|
PI [%] |
84.2±9.6 |
91.1±11.2 |
0.231 |
|
ALB [g/dL] |
3.6±0.21 |
4.2±0.36 |
0.342 |
|
Υ-gl [g/dL] |
1.92±0.5 |
1.4±0.4 |
0.02* |
ALB: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CHC: Chronic hepatitis C; CRP: C-reactive protein; Υ-gl: Gamma-globulins; GGT: Gamma-glutamyl transferase; ESR: Erythrocyte sedimentation rate; Hb: Hemoglobin; HCV-RNA: Hepatitis C viral load (viremia); IL-6: Interleukin-6; PI: Prothrombin index; PLT: Platelets; RNA: Ribonucleic acid; TB: Total bilirubin; TD: Thyroid disorder; TNF-α: Tumoral necrosis factor-alpha; WBC: White blood cells. *Highly statistically significant