Table 4. Data Table illustrating the study characteristics and findings for final articles included in this systematic review .

VERA - weaRable hAptic devices; RCT- randomized controlled trial; VR - virtual reality, GR - gesture recognition; BBS - Berg Balance Scale; FGA - Functional Gait Assessment; TUG - Timed Up and Go Test; FRT - Functional Reach Test; ERSP - event-related spectral perturbations; RAGT - robotic-assisted gait therapy; VRRT - virtual reality reflection therapy; RIMT - Reinforcement-Induced Movement Therapy.

Author & year of publication	Rehabilitation outcome target	Intervention	Number of patients	Type of study	Result	Conclusion
Bortone et al. (2020) [25]	Upper extremity function in Cerebral Palsy	weaRable hAptic devices (VERA), cross over with manual therapy	8	Pilot cross over RCT	Improvement in upper extremity function in both control and experimental group	No statistically significant difference between both groups
Ögün et al. (2019) [26]	Post-stroke upper extremity function	Leap Motion-based 3D immersion VR	65	RCT	Improvement in upper extremity function	Statistically significant upper extremity motor improvement in the experimental group (p<0.05) assessed with the Fugl-Meyer Upper Extremity Scale
Choi et al. (2019) [27]	Post-stroke upper extremity function	Gesture recognition (GR) device mirror therapy	36	RCT	Improvement in upper extremity function	Statistically significant motor improvement in the GR group as compared to conventional mirror therapy group (p<0.05)
Oh et al. (2019) [28]	Post-stroke upper extremity function and cognitive function	VR + real instrument training	31	RCT	Improvement in upper extremity function	Statistically significant motor improvement in the experimental group for wrist extension (p< 0.04) and elbow flexion (p<0.022)
Feng et al. (2019) [29]	Parkinson’s disease balance and gait	VR training rehabilitation	28	RCT	Improved balance and gait	Statistically significant motor improvement in the experimental group (p < 0.05) across many scales: Berg Balance Scale (BBS), Functional Gait Assessment (FGA), and Timed Up and Go Test (TUG)
Park et al. (2019) [30]	Post-stroke upper extremity function	VR based planar motion exercise apparatus	26	Pilot RCT	Improvement in upper extremity function	Significant difference in motor function in both groups (p<0.05). Increased range of motion in the experimental group versus control for should abduction and internal rotation (non-statistically significant)
Lee et al. (2018) [31]	Post-stroke postural balance and upper extremity function	Game-based VR canoe paddling	30	RCT	Improvement in both balance and upper extremity function	Statistically significant motor improvement in upper extremity function and postural balance (p<0.05)
Karasu et al. (2018) [32]	Post-stroke static and dynamic balance	Nintendo Wii + conventional therapy	23	RCT	Improved in many categories	Motor improvement in both groups (non-statistically significant primary outcome), however group-time secondary outcome shows significant difference in the experimental group (p<0.001) for BBS and Functional Reach Test (FRT)
Bergmann et al. (2018) [33]	Post-stroke gait	VR augmented robotic-assisted gait therapy (RAGT)	20	Pilot RCT	Improved gait and motivation	Increased motivation in the experimental group, this group spent more time walking on the robot compared to the control group (<0.03). Statistically significant difference on the Functional Ambulation Classification (p<0.01) after intervention in both control and experimental group
Gandolfi et al. (2017) [34]	Parkinson’s disease balance and gait	Virtual Telerehabilitation using Nintendo Wii	76	RCT	Reduced postural instability	Statistically significant motor improvement in VR Telerehabilitation group compared to in-clinic rehabilitation group (p=0.04) on Berg Balance Scale
Calabrò et al. (2017) [35]	Post-stroke gait and balance	RAGT + VR (2D animated avatar) interaction using EEG oscillations	24	Pilot RCT	Improvement in gait and balance	RAGT + VR (experimental group) showed higher event-related spectral perturbations (ERSP) in specific fronto-central cortical affected brain areas as compared to the control group
In et al. (2016) [16]	Post-stroke postural balance and gait	Virtual reality reflection therapy (VRRT)	25	RCT	Improvement in many categories	Statistically significant improvement (p<0.05) in VRRT group across various scales such as postural sway, Functional Reach Test, BBS, and TUG
Ballester et al. (2016) [36]	Post-stroke upper extremity function	Reinforcement-Induced Movement Therapy (RIMT)	18	RCT	Motor improvement with RIMT	Statistically significant motor improvement 12 weeks post-trial (p<0.05)