TABLE 1.
Proteomic analysis of NK3.3-derived EVs listed by abundance.
| Protein | Accession ID | Function |
| Actin | P60709 | Cytoskeleton component |
| CCL5 (RANTES) | P13501 | Chemokine |
| HLA class II DR, DQ | P01903, P01920 | Antigen presentation |
| Granzyme B | P10144 | Cytotoxic function |
| HSP90 | P07900 | Heat shock protein; chaperone |
| Granzyme A | P12544 | Cytotoxic function |
| CD70 | P32970 | Cytokine; TNF family member; immune activation |
| Ezrin, moesin | P15311, P26038 | Actin filament binding proteins |
| CD45 | P08575 | Hematopoietic cell membrane phosphatase |
| HLA class I A, B | P30512, P30495 | Antigen presentation |
| FcRγ | P30273 | CD16 signaling adapter protein |
| CD63 | P08962 | Tetraspanin EV protein |
| CD48 | P09326 | CD2 SLAM subfamily costimulatory molecule |
| CD59 | P13987 | Cell surface complement inhibition; CD2 ligand |
| Perforin | P14222 | Cytotoxic function |
| HSP70 | P0DMV8 | Heat shock protein; chaperone |
| CD2 | P06729 | Costimulatory adhesion molecule |
| CD47 | Q08722 | Integrin-associated molecule; “don’t eat me” |
| ICAM1 | P05362 | Integrin binding transmembrane protein |
| CD53 | P19397 | Tetraspanin adhesion molecule |
| LFA-1 (CD11a/CD18) | P20701, P05107 | Integrin; adhesion and costimulatory molecule |
| TNFSF4 | P23510 | Cytokine and chemokine regulation |
| CD82 | P27701 | Tetraspanin EV protein |
| CCR7 | P32248 | Chemokine |
| TNFRSF18 | Q9Y5U5 | Cytokine receptor; apoptosis; STAT1 phosphorylation |
| CD44 | P16070 | Cell adhesion; immune response |
| CD86 | P42081 | CD28 binding costimulatory molecule |
| CD166 | Q13740 | Leukocyte adhesion molecule |
| VCAM1 | P19320 | Integrin binding adhesion molecule |
| ICAM3 | P32942 | Integrin binding adhesion molecule |
| IL2Rβ | P14784 | High affinity IL-2 receptor β chain |
| PDCD6IP (ALIX) | Q8WUM4 | Exosome biogenesis |