Table 1.
Ligand-receptor pairs that have been de-orphanized to date using this approach.
| LIGAND/HORMONE | COGNATE RECEPTOR | POSSIBLE APPLICATIONS |
|---|---|---|
| Pro-insulin Connecting Peptide (C-Peptide)8 | GPR146 | Diabetes, vascular diseases |
| Phoenixin6,9,10 | GPR173 | Reproductive assist, fluid and electrolyte homeostasis |
| Adropin11 | GRP19 | Metabolic disorders, obesity |
| Neuronostatin5 | GPR107 | Metabolic disorders, diabetes |
| Cocaine- and amphetamine regulated transcript peptide (CARTp)16,17 | GPR160 | Pain management, appetite regulation, obesity |