Table III.
Predicted target genes of differentially expressed miRNAs both in bone tissue and osteocytes.
| miRNA | Target gene | Gene description | (Refs.) |
|---|---|---|---|
| miR-5118 | DKK2 | Dickkopf homolog 2 | (63) |
| Wnt2b | Wingless related MMTV integration site 2b | (51) | |
| Fzd5 | Frizzled homolog 5 | (64) | |
| Tgfbr1 | Transforming growth factor β receptor | (40,41) | |
| miR-433-3p | Creb1 | cAMP responsive element binding protein 1 | (61) |
| Map2 | Microtubule-associated protein 2 | (62) | |
| miR-190a-5p | Smad2 | SMAD family member 2 | (39,47) |
| miR-470-5p | DKK2 | Dickkopf homolog 2 | (63) |
| ATP2b1 | Plasma membrane calcium ATPase | (59) | |
| Runx2 | Runt related transcription factor 2 | (65) | |
| miR-3082-5p | Gria4 | Glutamate receptor ionotropic AMPA4 | (66,67) |
| Creb1 | cAMP responsive element binding protein 1 | (61) | |
| miR-6348 | Map3k12 | Activated protein kinase kinase kinase 12 | (33,34) |
| Dnm3 | Dynamin 3 | (68) | |
| miR-669-5p | Creb1 | cAMP responsive element binding protein 1 | (61) |
| Cask | Calcium/calmodulin-dependent serine protein kinase | (69) | |
| miR-32-3p | Tgfbr1 | Transforming growth factor β receptor | (40,41) |
| ATP13a3 | ATPase type 13A3 | (70,71) | |
| Dnm3 | Dynamin 3 | (68) |
Target genes related to osteogenic differentiation and bone metabolism are listed. miRNA/miR, microRNA.