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. 2021 Jul 15;22(3):1017. doi: 10.3892/etm.2021.10449

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Copyright: © Lin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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EA inhibits the proliferation of MCs induced by HG. (A) Chemical structure of EA. (B) Cytotoxicity of EA (1-80 µM) and LY294002 (20 µM) was detected via MTT assay in MCs treated with 5.5 mM glucose. (C) Effect of EA (10, 20 and 40 µM) and LY294002 (20 µM) on MC viability was detected using MTT assay. Effect of EA (10, 20 and 40 µM) and LY294002 (20 µM) on MC proliferation was (D) detected by EdU assay and (E) quantified. Scale bar, 40 µm. ^**P<0.01 vs. NC group; ^#P<0.05 and ^##P<0.01 vs. HG group. normal control (NC) group refers to 5.5 mM glucose treated cells. EA, ellagic acid; MCs, mesangial cells; OD, optical density; HG, high glucose; H-EA, high concentration EA intervention group; M-EA, medium concentration EA intervention group; L-EA, low concentration EA intervention group; NC, normal control; Glc, glucose; EdU, 5-ethynyl-2'-deoxyuridine.