Skip to main content
. 2021 Jul 15;22(3):1017. doi: 10.3892/etm.2021.10449

Figure 5.

Figure 5

PI3K agonist 740Y-P reverses the effect of EA on the PI3K/Akt signaling pathway and its downstream transcription factors in MCs treated with HG. (A) Western blotting was used to examine the effect of EA (40 µM) and/or 740Y-P (10 µM) treatment on (C) p-PI3K, (D) p-Akt and (E) SOD2 expression levels in MCs treated with HG (30 mM). (B) Western blotting was used to examine the effect of EA (40 µM) and/or 740Y-P (10 µM) treatment on intranuclear (F) p-NF-κB and (G) FOXO3a in MCs treated with HG (30 mM). **P<0.01 vs. HG group; ##P<0.01 vs. HG + EA group. HG, high glucose; MCs, mesangial cells; p-, phosphorylated; Glc, glucose; EA, ellagic acid; SOD2, superoxide dismutase 2.