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. 2021 Jul 18;22(3):1028. doi: 10.3892/etm.2021.10460

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PA-induced insulin resistance downregulates the expression of KLF4 in macrophages. (A) 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose uptake detection. (B) Representative western blots and (C) semi-quantification of the protein expression levels of insulin resistance-related proteins. (D) Representative western blots and (E) semi-quantification of KLF4 protein expression levels. ELISA detection of the levels of (F) IL-6, (G) IL-1β and (H) TNF-α following treatment with different concentrations of PA. ^*P<0.05 and ^**P<0.01 vs. control. IL, interleukin; INSR, insulin receptor; IRS1, insulin receptor substrate 1; KLF4, Krüppel-like factor 4; p, phosphorylated; PA, palmitic acid; TNF-α, tumor necrosis factor α.