Table 3. Results of studies investigating the relationship between ADAM12 (rs1871054 and rs3740199) polymorphisms and knee OA.
| Study | Population | SNPs | Pathologic findings | Results in sex |
|---|---|---|---|---|
| Kerna et al. (2009) | Estonian population | rs3740199 | PFKOA | M (+) |
| rs1871054 | PFKOA | F (-) | ||
| M/F (-) | ||||
| Kerna et al. (2013)* | Estonian population | rs1871054 | Advance stage OA osteophyte formation | M/F (+) |
| Wang et al. (2015) | Chinese Han population | rs3740199 | PFKOA | M/F (-) |
| rs1871054 | ||||
| Lou et al. (2014) | Chinese Han population | rs3740199 | PFKOA | M/F (-) |
| rs1871054 | PFKOA susceptibility | M/F (+) | ||
| Poonpet et al. (2016) | Thai population | rs3740199 | PFKOA susceptibility | M (+) |
| F (-) | ||||
| OA: Osteoarthritis; SNPs: Single nucleotide polymorphisms; PFKOA: Patellofemoral knee osteoarthritis; M: Male; F: Female; * Study with different radiographic classification system in same population | ||||