Table 3.
Parameter estimates for the final model and bootstrap
| Parameter | Mean estimate of the final model ± SE | Bootstrap median result (95% confidence interval) |
|---|---|---|
| Central volume (Vc) (L) | 15.87 ± 3.99 | 15.86 (10.85–37.35) |
| Peripheral colume (Vp) (L) | 4.11 ± 0.99 | 4.11 (1.34–19.33) |
| Clearance (CL) (L/h) | 4.64 ± 0.56 | 4.64 (3.58–7.34) |
| Intercompartmenral clearance (Q) (L/h) | 0.62 ± 0.11 | 0.63(0.43–1.69) |
| Between subject variability associated with Vc (%) | 37.80% | 35.53% |
| Between subject variability associated with CL (%) | 27.89% | 27.00% |
| Additive error (mg/L) | 0.011 | 0.011 |