Table-7. Optimum Formulations That Proposed by Design-Expert Software .
| Formulations | CP (mg) |
CCS (mg) |
SSG (mg) |
SB (mg) |
CA (mg) |
Friability (%) | Disintegration time (sec) | ||
| E | O | E | O | ||||||
| OS | 7.09 | 6.74 | 4.84 | 0.39 | 0.38 | 16.97 | 17.36 | ||
| OE | - | - | - | 34.70 | 26.52 | 0.39 | 0.39 | 47.90 | 46.21 |
| OSE | 9.97 | - | - | 36 | 30.96 | 0.38 | 0.37 | 11.89 | 12.35 |
SSG: Sodium starch glycolate; CCS: Croscarmellose sodium; CP: Crospovidone; SB: Na bicarbonate; CA: Citric acid; E: Estimated; O: Obtained; OS: Optimum Superdisintegrant formulation, OE: Optimum Effervescent formulation; OSE: Optimum Superdisintegrant and Effervescent formulation