Table-8. Evaluation of Physicochemical Characteristics of Mixed Powders .
| Formulations | Physicochemical properties (mean ±SD) | ||||
|
Bulk density
(g/cm 3 ) |
Tapped density(g/cm 3 ) | Angle of repose | Husner’s ratio | Compressibility index (%) | |
| F 1 | 0.59±0.03 | 0.66±0.03 | 24.67±0.91 | 1.12±0.02 | 5.02±0.21 |
| F 2 | 0.64±0.02 | 0.65±0.08 | 26.54±1.16 | 1.01±0.01 | 7.34±0.12 |
| F 3 | 0.61±0.02 | 0.67±0.04 | 25.52±0.88 | 1.10±0.01 | 6.89±0.18 |
| F 4 | 0.58±0.03 | 0.65±0.02 | 28.36±0.98 | 1.12±0.04 | 8.35±0.16 |
| F 5 | 0.60±0.01 | 0.68±0.06 | 25.89±1.01 | 1.13±0.02 | 6.05±0.13 |
| F 6 | 0.63±0.04 | 0.67±0.01 | 27.33±0.93 | 1.06±0.03 | 7.76±0.23 |
| F 7 | 0.62±0.07 | 0.65±0.04 | 26.96±1.08 | 1.05±0.06 | 8.32±0.14 |
| F 8 | 0.64±0.04 | 0.66±0.02 | 25.09±0.90 | 1.03±0.03 | 4.97±0.19 |
| F 9 | 0.62±0.02 | 0.68±0.07 | 26.22±1.13 | 1.10±0.05 | 5.68±0.10 |
| F 10 | 0.65±0.03 | 0.66±0.09 | 28.98±0.98 | 1.01±0.02 | 9.01±0.27 |
| F 11 | 0.59±0.08 | 0.65±0.03 | 26.39±1.09 | 1.10±0.07 | 8.87±012 |
| F 12 | 0.64±0.07 | 0.68±0.05 | 27.69±1.12 | 1.06±0.08 | 7.56±0.16 |
| F 13 | 0.62±0.05 | 0.66±0.07 | 29.01±1.15 | 1.06±0.02 | 5.97±0.20 |
| F 14 | 0.66±0.04 | 0.69±0.09 | 28.69±0.99 | 1.04±0.04 | 8.34±0.19 |
| F 15 | 0.62±0.02 | 0.66±0.02 | 26.48±1.08 | 1.06±0.03 | 6.64±0.14 |
| F 16 | 0.63±0.06 | 0.68±0.04 | 27.99±0.95 | 1.08±0.06 | 5.83±0.15 |
| F 17 | 0.59±0.08 | 0.65±0.07 | 25.47±1.19 | 1.10±0.04 | 8.84±0.17 |
| F 18 | 0.63±0.02 | 0.68±0.04 | 26.64±1.14 | 1.08±0.03 | 5.76±0.23 |
| F 19 | 0.61±0.06 | 0.65±0.07 | 28.54±0.98 | 1.06±0.06 | 5.03±0.12 |
| F 20 | 0.63±0.03 | 0.67±0.05 | 27.08±1.02 | 1.06±0.02 | 5.93±0.13 |
| F 21 | 0.62±0.02 | 0.66±0.03 | 28.37±0.93 | 1.06±0.8 | 8.91±0.16 |
| F 22 | 0.58±0.08 | 0.64±0.04 | 26.78±0.93 | 1.10±0.01 | 7.98±0.18 |
| F 23 | 0.62±0.04 | 0.68±0.08 | 28.39±1.20 | 1.10±0.05 | 5.74±0.28 |
| F 24 | 0.65±0.03 | 0.67±0.05 | 28.91±0.92 | 1.03±0.03 | 6.99±0.12 |
| F 25 | 0.62±0.04 | 0.66±0.07 | 24.65±1.02 | 1.06±0.09 | 7.82±0.08 |
| F 26 | 0.62±0.05 | 0.68±0.04 | 25.63±0.94 | 1.10±0.02 | 6.68±0.13 |
| F 27 | 0.64±0.05 | 0.69±0.01 | 24.96±1.08 | 1.08±0.04 | 7.14±0.07 |
| F 28 | 0.63±0.03 | 0.64±0.06 | 26.04±1.23 | 1.02±0.03 | 8.13±0.21 |
| F 29 | 0.61±0.02 | 0.68±0.04 | 29.08±1.06 | 1.11±0.06 | 6.48±0.12 |
| F 30 | 0.62±0.06 | 0.67±0.07 | 27.64±0.96 | 1.08±0.02 | 7.56±0.19 |
| F 31 | 0.60±0.01 | 0.65±0.02 | 25.13±1.21 | 1.08±0.09 | 6.05±0.19 |
| OS | 0.59±0.06 | 0.64±0.09 | 26.17±1.32 | 1.08±0.03 | 6.32±0.41 |
| OE | 0.61±0.04 | 0.68±0.06 | 27.75±1.09 | 1.11±0.08 | 8.16±0.36 |
| OSE | 0.67±0.10 | 0.69±0.12 | 26.87±1.18 | 1.03±0.02 | 7.93±0.25 |
OS: Optimum Superdisintegrant formulation; OE: Optimum Effervescent formulation; OSE: Optimum Superdisintegrant and Effervescent formulation