Figure 6.

Comparison of therapeutic effects of dexrazoxane (DEX) and TPCD NP in mice with DOX-induced heart failure. (A) Schematic illustration of the treatment protocols. (B) The heart weight of different groups. (C) Ratios of HW/TL for different groups. (D) Representative M-mode echocardiography images of mouse hearts after different treatments. (E-F) LVEF and LVFS quantified by echocardiography. (G-H) The levels of MDA (G) and H₂O₂ (H) in tissue homogenates of hearts isolated from mice treated with different formulations. The total protein content in heart homogenates was measured by the BCA assay. (I-J) Serum levels of cTnI (I) and CK (J). Control, healthy mice treated with saline; DOX, mice treated with DOX and saline; DEX, mice treated with DOX and DEX at 200 mg/kg; TPCD NP, mice treated with DOX and TPCD NP at 25 mg/kg. Data in (B-C,E-J) are mean ± SD (n = 5). Statistical significance was assessed by the one-way ANOVA with post-hoc LSD tests. *P < 0.05, **P < 0.01, ***P < 0.001.