Table 1.

Advantages and disadvantages of five TPD technologies

POIs	Techs	Advantages	Disadvantages
Intracellular proteins	PROTAC	Clear mechanisms of action 49; event-driven action 50; catalytic degradation activity 51;	Limitation to cytosolic domain of proteins 36; In a proteasome-dependent manner 45; Poor cellular penetration needs to be solved 36
	AUTAC	Targeting organelles and intracellular proteins; selective autophagy 11,39	Degradation mechanisms need further investigation 11,39
	ATTEC	Low molecular weight; selective degradation; Drug-like property 12	Hard to design 12
Extracellular and membrane-bound proteins	LYTAC	Targeting extracellular and membrane-bound proteins 21; high selectivity in POIs and cell types 23,24	Poor tissue permeability 21; Complex synthesis of LTR ligands M6Pn 21; Possible immune response in vivo 52; Lack of studies
	AbTAC	Targeting membrane proteins; high bispecificity 22	High cost; Potential immunogenicity 53; Unclear endocytosis mechanism 22