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Advantages and disadvantages of POI ligands
| Advantages | Disadvantages | |
|---|---|---|
| Antibodies | Specific affinity with POIs 74 | High cost; low stability and tissue permeability 21; potential immunogenicity 52 |
| Small molecules | High stability 75; good penetrability 25 |
Inability to target “undruggable proteins” 25 |
| Peptides | Low cost; easy to synthesise 61 |
Low stability; limited penetrability 36 |
