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. 2021 Jul 13;11(17):8129–8142. doi: 10.7150/thno.62069

Figure 2.

Figure 2

Treatment with hMSC-derived EVs ameliorate cognitive decline of 5XFAD mice. (A) Mice were tested for memory using novel object recognition test (NORT). hMSC-EV treated 5XFAD mice performed significantly better than saline treated 5XFAD mice. N=6. (B) Y-maze test was used to determine spatial working memory. hMSC-EV treated 5XFAD mice performed significantly better than saline treated 5XFAD mice. N=6. Finally, mice were tested for spatial learning and memory using the Barnes maze. hMSC-EV treated 5XFAD mice performed significantly better on both (C) primary escape time and (D) primary escape error. One-way ANOVA was used to determine the statistical significance of A and B. Two-way ANOVA was used to assess the significance of C and D. N=5. *P < 0.05; **P < 0.01.