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Illustration of (A) AF9 or ENL protein, (B) MLL-AF9/-ENL fusion oncoprotein, and (C) Functions of MLL-AF9. MLL binds to its target gene promoters, with the AHD domain of AF9 recruiting DOT1L for H3K79 methylation, or AF4/AFF4, ELL and P-TEFb for transcription elongation.
