Table 2.

HLA-DRB1*, -DQB1*, and -DQA1* alleles distribution in patients with severe DR and patients without DR

	Patients with severe DR N  =  117		Patients without DR N  =  117		OR	(CI)	p
	N	(%)	N	(%)
HLA-DRB1*
01:01	6	(2.56)	8	(3.42)	0.74	(0.25–2.18)	0.59
01:02	5	(2.14)	6	(2.56)	0.83	(0.25–2.76)	0.76
03:01	68	(29.06)	80	(34.19)	0.79	(0.53–1.16)	0.23
04:01	8	(3.42)	15	(6.41)	0.52	(0.21–1.24)	0.13
04:02	13	(5.56)	14	(5.98)	0.92	(0.42–2.01)	0.84
04:04	8	(3.42)	10	(4.27)	0.79	(0.31–2.05)	0.63
04:05	35	(14.96)	24	(10.26)	1.54	(0.88–2.68)	0.13
07:01	18	(7.69)	23	(9.83)	0.76	(0.40–1.46)	0.41
09:01	4	(1.71)	10	(4.27)	0.39	(0.12–1.26)	0.10
13:02	15	(6.41)	4	(1.71)	3.94	(1.29–12.05)	0.01
Others	54	(23.08)	40	(17.09)	1.45	(0.92–2.30)	0.11
HLA-DQA1*
01:01 g	17	(7.26)	21	(8.97)	0.79	(0.41–1.55)	0.49
01:02	24	(10.26)	15	(6.41)	1.67	(0.85–3.27)	0.13
01:03	5	(2.14)	3	(1.28)	1.68	(0.40–7.12)	0.48
02:01	17	(7.26)	22	(9.40)	0.75	(0.39–1.46)	0.40
03:01 g	74	(31.62)	77	(32.91)	0.94	(0.64–1.39)	0.77
04:01	12	(5.13)	6	(2.56)	2.05	(0.76–5.57)	0.14
04:02	1	(0.43)	0	(0.00)			NA
05:01 g	82	(35.04)	90	(38.46)	0.86	(0.59–1.26)	0.44
05:10	2	(0.85)	0	(0.00)			NA
HLA-DQB1*
02:01	71	(30.34)	81	(34.62)	0.82	(0.56–1.21)	0.32
02:02	23	(9.83)	35	(14.96)	0.62	(0.35–1.09)	0.09
03:01 g	22	(9.40)	11	(4.70)	2.10	(1.0–4.44)	0.047
03:02	60	(25.64)	58	(24.79)	1.05	(0.69–1.59)	0.83
04:02	11	(4.70)	5	(2.14)	2.26	(0.77–6.61)	0.13
05:01	17	(7.26)	20	(8.55)	0.84	(0.43–1.64)	0.61
06:04	10	(4.27)	4	(1.71)	2.57	(0.79–8.30)	0.1
Others	20	(8.55)	20	(8.55)	1.00	(0.52–1.91)	1

Bold represents statistical significance (p < 0.05)

Rare alleles were included in others

DR diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval; NA non applicable