Table 3.
Distribution of the HLA-DRB1 ~ DQA1 ~ DQB1 haplotypes in patients with severe DR and patients without DR
| Haplotype | Patients with severe DR N = 117 | Patients without DR N = 117 | OR | (CI) | p | ||
|---|---|---|---|---|---|---|---|
| HLA-DRB1 ~ DQA1 ~ DQB1 | N | % | N | % | |||
| 03:01 ~ 05:01 g ~ 02:01 | 68 | (29.06) | 78 | (33.33) | 0.82 | (0.55–1.21) | 0.32 |
| 04:05 ~ 03:01 g ~ 03:02 | 33 | (14.10) | 20 | (8.55) | 1.75 | (0.97–3.16) | 0.06 |
| 07:01 ~ 02:01 ~ 02:02 | 16 | (6.84) | 21 | (8.97) | 0.74 | (0.38–1.46) | 0.39 |
| 04:02 ~ 03:01 g ~ 03:02 | 13 | (5.56) | 13 | (5.56) | 1.00 | (0.45–2.21) | 1 |
| 04:01 ~ 03:01 g ~ 03:02 | 5 | (2.14) | 13 | (5.56) | 0.37 | (0.13–1.06) | 0.05 |
| 04:04 ~ 03:01 g ~ 03:02 | 7 | (2.99) | 9 | (3.85) | 0.77 | (0.28–2.11) | 0.61 |
| 09:01 ~ 03:01 g ~ 02:02 | 4 | (1.71) | 8 | (3.42) | 0.49 | (0.15–1.65) | 0.24 |
| 13:02 ~ 01:02 ~ 06:04 | 10 | (4.27) | 2 | (0.85) | 5.18 | (1.12–23.90) | 0.02 |
| 01:01 ~ 01:01 g ~ 05:01 | 5 | (2.14) | 6 | (2.56) | 0.83 | (0.25–2.76) | 0.76 |
| Others | 73 | (31.20) | 64 | (27.35) | 1.2 | (0.81–1.80) | 0.36 |
Bold represents statistical significance (p < 0.05)
Rare alleles were included in others
DR diabetic retinopathy; N number of individuals; OR odds ratio; CI confidence interval