Table 4. Clinical Studies on Plants Used for Treatment of Vaginitis Mentioned in ‘‘the Canon of Medicine’’ .

Plant	Treatment group	Control group	Study design	Number of patients	Treatment duration	Result	References
Myrtus communis L.	Leaves vaginal gel in metronidazole base Paste containing Myrtle Fruit syrup	Vaginal gel of metronidazole Placebo paste Placebo syrup	Randomized clinical trial Double-blind, before–after RCT Double-blinded RCT	80 women 45 patients 45 patients	5 nights 6 days 3 months	Improve the efficacy of bacterial vaginosis therapy in myrtle group ↓The size of ulcers, Pain severity, The level of erythema, Exudation, Improving the quality of life in patients who suffer from RAS ↓ Mean number of vaginal bleeding days & ↓ use of pads in Myrtle group	[42] [43] [38]
Punica granatum L.Spreng.	Mouth rinsing with pomegranate extract(PomElla) Natural pomegranate juice Pomegranate extract Pomegranate juice	Mouth rinsing with placebo (corn muffin mix) Placebo drink Placebo drink Placebo drink	Randomized, single-blinded controlled trial Clinical trial Double-blind RCT Double-blind RCT	32 subjects (16 males, 16 females) 9 male elite weightlifters 48 participants 101 patients	4 weeks 15 days 30 days 1 year	↓Total protein and aspartate aminotransferase in the treatment group Accelerates recovery of muscle damage and soreness and inflammatory markers ↓Plasma inflammatory and oxidative stress biomarkers ↓Systemic inflammation and oxidative stress	[55] [56] [57] [58]
Qercusinfectoria Olive.	Topical ointment of Bensal HP (proprietary oak bark extract, Quercus rubra-3%)	SSC	Randomized, blinded controlled trial	40 patients	6 weeks	↓The Wound the diameter of the Bensal HP collective group	[69]

RAS: Recurrent aphthous stomatitis, RCT: Randomized controlled trial, SCC: Silver sulfadiazine cream